abstract：:Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways affected by chronic stress in brain have not been fully explored. We invest...

journal_title：Behavioural brain research

authors： Lu Q,Mouri A,Yang Y,Kunisawa K,Teshigawara T,Hirakawa M,Mori Y,Yamamoto Y,Libo Z,Nabeshima T,Saito K

更新日期：2019-10-17 00:00:00

abstract：:Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that can persist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcohol intake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occa...

journal_title：Behavioural brain research

authors： Balaszczuk V,Salguero JA,Villarreal RN,Scaramuzza RG,Mendez S,Abate P

更新日期：2019-10-17 00:00:00

abstract：:Maternal-deprivation of rodent pups is a relevant model of extreme early-life stress that can be relevant to the understanding of long-term effects of war, migration, parental loss and displacement. Although even mild stress during infancy affects brain development and behavior, the current study focused on the effect...

journal_title：Behavioural brain research

authors： Frank D,Zlotnik A,Kofman O,Grinshpun J,Severynovska O,Brotfain E,Kut R,Natanel D,Melamed I,Boyko M

更新日期：2019-10-17 00:00:00

abstract：:Prenatal exposure to polyriboinosinic-polyribocytidylic acid (poly I:C) results in psychotic-like behavior in mature rat offspring as well as enduring modifications of glutamatergic excitatory synaptic transmission. However, little is known about the dynamic behavioral and glutamate N-methyl-D-aspartate (NMDA) recepto...

journal_title：Behavioural brain research

authors： Hao K,Su X,Luo B,Cai Y,Chen T,Yang Y,Shao M,Song M,Zhang L,Zhong Z,Li W,Lv L

更新日期：2019-09-16 00:00:00

abstract：:Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisi...

journal_title：Behavioural brain research

authors： Packheiser J,Güntürkün O,Pusch R

更新日期：2019-09-16 00:00:00

abstract：:The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 rec...

journal_title：Behavioural brain research

authors： An J,Zhou Y,Zhang M,Xie Y,Ke S,Liu L,Pan X,Chen Z

更新日期：2019-09-16 00:00:00

abstract：:Aerobic training has a neuroprotective effect, reduces the risk of developing neurodegenerative diseases and facilitates functional recovery. The present study assesses the effect of aerobic training on cognitive functions, hippocampal BDNF/TrkB ligand receptor system expression and serum levels of BDNF and corticoste...

journal_title：Behavioural brain research

authors： Shishmanova-Doseva M,Georgieva K,Koeva Y,Terzieva D,Peychev L

更新日期：2019-09-16 00:00:00

abstract：:The 3xTg-AD mouse model of Alzheimer's disease (AD) has both amyloid beta plaque and tau tangle pathology. However, the results of behavioural testing with these mice have been inconsistent due to age- and sex-related differences, as well as differences in the difficulty of the tests used to measure cognitive function...

journal_title：Behavioural brain research

authors： Fertan E,Wong AA,Vienneau NA,Brown RE

更新日期：2019-09-16 00:00:00

abstract：:Although the dorsal hippocampus (DH) plays an essential role in the consolidation of contextual fear-conditioned (CxFC) memory, this consolidation may also occur in the absence of DH. It is, however, not known if the development of a compensatory circuit for CxFC memory is time-dependent. The DH-dependent contextual f...

journal_title：Behavioural brain research

authors： Kant D,Jha SK

更新日期：2019-09-16 00:00:00

abstract：:Initiation of ketamine use often occurs in adolescence, yet little is known about long-term consequences when use begins in this developmental period. The current experiments were designed to examine the effects of repeated exposure to ketamine in adolescence on behavior in adulthood. We examined locomotor activity, a...

journal_title：Behavioural brain research

authors： Bates MLS,Trujillo KA

更新日期：2019-09-02 00:00:00

abstract：:Exposure to severe or persistent social stress may lead to the development of psychiatric disorders such as anxiety and depression. These mood disorders are associated with structural alterations of neural architecture in limbic brain regions that control emotion, mood and cognition. Structural remodeling may either b...

journal_title：Behavioural brain research

authors： Patel D,Kas MJ,Chattarji S,Buwalda B

更新日期：2019-09-02 00:00:00

abstract：:Fetal ethanol experience generates learning and memories capable to increase ethanol consummatory behaviors during infancy. Opioid system seems to be involved in mediating those alcohol-related behaviors. In this work, we proposed to study the impact of prenatal exposure to a moderate ethanol dose, upon ingestion of t...

journal_title：Behavioural brain research

authors： Guttlein L,Macchione AF,Hernández-Fonseca K,Haymal OB,Molina JC,Méndez Ubach M,Abate P

更新日期：2019-08-05 00:00:00

abstract：:Mild traumatic brain injury is a common outcome of blast exposure, and current literature indicates high rates of comorbid posttraumatic stress disorder (PTSD) in military personnel. Blast-exposed rats display PTSD-like behavior, suggesting relationships may exist between PTSD and blast exposure. Other studies demonst...

journal_title：Behavioural brain research

authors： Statz JK,Ciarlone SL,Goodrich JA,McCarron RM,Walker PB,Norris JN,Ahlers ST,Tschiffely AE

更新日期：2019-08-05 00:00:00

abstract：:Surgical trauma can cause brain oxidative stress and neuroinflammation, leading to postoperative cognitive dysfunction (POCD), especially in the elderly. Additionally, the pre-existing risk factors may enhance POCD. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has recently been shown to contribute t...

journal_title：Behavioural brain research

authors： Meng F,Li N,Li D,Song B,Li L

更新日期：2019-08-05 00:00:00

abstract：:The lateral septal nucleus (LSN) is related to the actions of antidepressants, and the prelimbic cortex (PL) and infralimbic cortex (IL) modulate responses to fear. However, unknown is whether experimental diabetes that is induced by alloxan alters the responsivity of these regions. We used a method in which one foreb...

journal_title：Behavioural brain research

authors： Contreras CM,Gutiérrez-García AG,Moreno-Cortés ML

更新日期：2019-08-05 00:00:00

abstract：:L-DOPA (L-3,4-dihydroxyphenylalanine) relieves symptoms of Parkinson disease (PD), but long-term use can cause serious side effects. Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RV), a polyphenolic compound derived from grapes and red wine that has antioxidant activity, has been shown to have neuroprotective effects...

journal_title：Behavioural brain research

authors： Liu Q,Zhu D,Jiang P,Tang X,Lang Q,Yu Q,Zhang S,Che Y,Feng X

更新日期：2019-07-23 00:00:00

abstract：:The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. These disorders feature high levels of comorbidity and share an overlap of symptoms; in particular, deficits in social functioning...

journal_title：Behavioural brain research

authors： Redecker TM,Kisko TM,Schwarting RKW,Wöhr M

更新日期：2019-07-23 00:00:00

abstract：:Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The under...

journal_title：Behavioural brain research

authors： El Khiat A,Tamegart L,Draoui A,El Fari R,Sellami S,Rais H,El Hiba O,Gamrani H

更新日期：2019-07-23 00:00:00

abstract：:Strategic processing allows for value-based preferential encoding of information. Event-related spectral perturbations can provide insights into neural processes linked to the different aspects of strategic processing. This study examined theta and alpha band power differences linked to processing of high- versus low-...

journal_title：Behavioural brain research

authors： Nguyen LT,Marini F,Zacharczuk L,Llano DA,Mudar RA

更新日期：2019-07-23 00:00:00

abstract：:Epigenetic modulation of brain-derived neurotrophic factor (BDNF) provides one possible explanation for the dysfunctions induced by stress, such as psychiatric disorders and cognitive decline. Interestingly, social support can be protective against some of these effects, but the mechanisms of social buffering are poor...

journal_title：Behavioural brain research

authors： Viana Borges J,Souza de Freitas B,Antoniazzi V,de Souza Dos Santos C,Vedovelli K,Naziaseno Pires V,Paludo L,Martins de Lima MN,Bromberg E

更新日期：2019-07-02 00:00:00

abstract：:Nav1.1 and Nav1.2 are the voltage-gated sodium channel alpha subunit1 and 2, encoded by the genes of SCN1A and SCN2A. Previous studies have shown that chronic cerebral hypoperfusion (CCH) could induce neuropathological and cognitive impairment and increased total Nav1.1 and Nav1.2protein levels, yet the detailed mecha...

journal_title：Behavioural brain research

authors： Hu XL,Wang XX,Zhu YM,Xuan LN,Peng LW,Liu YQ,Yang H,Yang C,Jiao L,Hang PZ,Sun LH

更新日期：2019-07-02 00:00:00

abstract：:Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we...

journal_title：Behavioural brain research

authors： Huang N,Li Y,Zhou Y,Zhou Y,Feng F,Shi S,Ba Z,Luo Y

更新日期：2019-06-03 00:00:00

abstract：:Ghrelin is a recently discovered peptide, mainly produced in the stomach and involved in body's energy-maintenance processes. Ghrelin exerts its actions by activating the growth hormone secretagogue receptor (GHS-R). Recent analyses indicate that ghrelin targets the brain to regulate a wealth of functions, including b...

journal_title：Behavioural brain research

authors： Cavalcante DP,Turones LC,Camargo-Silva G,Santana JS,Colugnati DB,Pansani AP,Xavier CH,Henschel Pobbe RL

更新日期：2019-06-03 00:00:00

abstract：:Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and...

journal_title：Behavioural brain research

authors： Hess A,Kress S,Rakete S,Muench G,Kornhuber J,Pischetsrieder M,Müller CP

更新日期：2019-05-17 00:00:00

abstract：:Autism-affected individuals are characterized by lower plasma oxytocin and its ectoenzyme regulator CD38. Oxytocin, a hypothalamic hormone secreted upon the release of CD38, plays a role in social behavior and bonding. All-trans retinoic acid is a potent inducer of CD38 and can be used as a novel therapeutic strategy ...

journal_title：Behavioural brain research

authors： Avraham Y,Berry EM,Donskoy M,Ahmad WA,Vorobiev L,Albeck A,Mankuta D

更新日期：2019-05-17 00:00:00

abstract：OBJECTIVE:Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The present study was designed to examine whether early cognitive alterat...

journal_title：Behavioural brain research

authors： Zhang P,Pan J,Mao Z,Xu X,Lin D,Wu B,Zhou W,Liu Y

更新日期：2019-05-02 00:00:00

abstract：:Despite substantial increases in the use of antipsychotics to treat various psychiatric conditions in children, there is a lack of literature regarding long-term effects of early treatment. Some studies have indicated that early administration results in differential alterations to neurotransmission systems, but few s...

journal_title：Behavioural brain research

authors： Boman L,De Butte M

更新日期：2019-05-02 00:00:00

abstract：:Several executive functions decline with the development of type-1 diabetes (T1D), particularly working memory (WM). In adults, WM ensures efficient cognitive processing by focusing on task-relevant information while suppressing distractors. It has been well documented that WM can be influenced by emotional stimuli, w...

journal_title：Behavioural brain research

authors： González-Garrido AA,Gallardo-Moreno GB,Gómez-Velázquez FR

更新日期：2019-05-02 00:00:00

abstract：:Astrocyte dysfunction is implicated in clinical depression. There is a paucity of animal models to assess the role of astrocytes in depression pathogenesis. Refinement of an existing model is described here. Administration of the astrocytic toxin L-alpha aminoadipic acid (L-AAA) to the pre-limbic cortex (PLC) was asse...

journal_title：Behavioural brain research

authors： David J,Gormley S,McIntosh AL,Kebede V,Thuery G,Varidaki A,Coffey ET,Harkin A

更新日期：2019-04-19 00:00:00

abstract：:Chemotherapy related cognitive impairment (CTRC; "chemobrain") is a syndrome that is associated with the impairment of various aspects of cognition, including executive function, processing speed, and multitasking. The role of neurotransmitter release in the expression of cognitive impairments is not well known. In th...

journal_title：Behavioural brain research

authors： Jarmolowicz DP,Gehringer R,Lemley SM,Sofis MJ,Kaplan S,Johnson MA

更新日期：2019-04-19 00:00:00

abstract：:Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number ...

journal_title：Behavioural brain research

authors： Ghanem E,Al Bitar S,Dib R,Kabrita CS

更新日期：2019-04-19 00:00:00

abstract：:In the olfactory epithelium, olfactory sensitive neurons and their axons are surrounded by glia-like cells called sustentacular cells, which maintain both the structural and ionic integrity of the olfactory mucosa. We have previously found that endothelin-1 (ET-1) can uncouple sustentacular cell gap junctions in vitro...

journal_title：Behavioural brain research

authors： Bryche B,Le Bourhis M,Congar P,Martin C,Rampin O,Meunier N

更新日期：2019-04-19 00:00:00

abstract：:Diminished dopamine D1 stimulation may contribute to cognitive impairment in Alzheimer's and Parkinson's diseases, schizophrenia, and other neuropsychiatric disorders. However, orthosteric D1 receptor (D1R) agonists produce receptor desensitization and an inverted U-shaped dose-response curve, but positive allosteric ...

journal_title：Behavioural brain research

authors： Meltzer HY,Rajagopal L,Matrisciano F,Hao J,Svensson KA,Huang M

更新日期：2019-04-01 00:00:00

abstract：:Exposure to social stress increases the vulnerability of experimental animals to the rewarding effects of cocaine and it has been suggested that the glutamatergic system could be involved in these effects of stress. The aim of this work is to determine the role of N-methyl-d-aspartate (NMDA) glutamate receptors in the...

journal_title：Behavioural brain research

authors： García-Pardo MP,Calpe-López C,Miñarro J,Aguilar MA

更新日期：2019-04-01 00:00:00

abstract：:Social norms are a common motivator or de-motivator of behavior through the need of humans to comply with acceptable behaviors of their social groups. Converging evidence from functional neuroimaging and noninvasive brain stimulation studies suggest that the right dorsolateral prefrontal cortex (rDLPFC) is involved in...

journal_title：Behavioural brain research

authors： Chen W,Zhang S,Turel O,Peng Y,Chen H,He Q

更新日期：2019-04-01 00:00:00

abstract：:Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to the use of invertebrate model systems to comp...

journal_title：Behavioural brain research

authors： Jackson C,van Staaden M

更新日期：2019-04-01 00:00:00

abstract：:The present study was aimed at evaluating whether the differences between the Roman high- (RHA) and low-avoidance (RLA) rat strains in novelty-induced behavioural inhibition/disinhibition, sensorimotor gating (i.e., prepulse inhibition, PPI) and spatial learning/memory parallel differences in the volume of brain areas...

journal_title：Behavioural brain research

authors： Río-Álamos C,Piludu MA,Gerbolés C,Barroso D,Oliveras I,Sánchez-González A,Cañete T,Tapias-Espinosa C,Sampedro-Viana D,Torrubia R,Tobeña A,Fernández-Teruel A

更新日期：2019-04-01 00:00:00

abstract：:Non-human primates have become one of the most important model animals for the investigation of brain diseases because they share a wide-range of genetics and social similarities with human beings. Naturally-evoked depression models in macaques may offer a full spectrum of similarity to human depression states, but th...

journal_title：Behavioural brain research

authors： Chu X

更新日期：2019-03-15 00:00:00

abstract：:Somatic and motivational symptoms accompanying opiate withdrawal are considered one of the major reasons for relapse to opiate-seeking and opiate-taking behaviors. These symptoms are accompanied by the activation of stress-related processes including hypothalamic-pituitary-adrenal axis activity and noradrenergic (NA) ...

journal_title：Behavioural brain research

authors： Solecki WB,Kus N,Gralec K,Klasa A,Pradel K,Przewłocki R

更新日期：2019-03-15 00:00:00

abstract：:Although it is well documented that exposure to aversive stimuli induces modulation of neural circuits and subsequent behavioral changes, the means by which an aversive stimulus concomitantly alters behaviors of different natures (e.g., defensive and appetitive) remains unclear. Here, we addressed this issue by using ...

journal_title：Behavioural brain research

authors： Farruggella J,Acebo J,Lloyd L,Wainwright ML,Mozzachiodi R

更新日期：2019-03-15 00:00:00